During metazoan animal development, changes in chromatin states give rise to diverse patterns of gene expression that direct the differentiation of progenitor cells into various tissues and organs. We use information from TF binding motifs and chromatin accessibility data to infer cell-type specific TF occupancy, and incorporate inferred TF-target interactions as prior knowledge to learn mammalian gene regulatory networks alongside compendia of gene expression data.

Moore Sloan Poster Research Project